Description
Arimidex is a highly selective non-steroidal inhibitor of aromatase, an enzyme that converts androstenedione in peripheral tissues in postmenopausal women into estrone and then into estradiol. Reducing circulating estradiol levels in breast cancer patients has a therapeutic effect. In postmenopausal women Arimidex in a daily dose of 1 mg causes a decrease in estradiol levels by 80%.
Arimidex has no progestogenic, androgenic and estrogenic activity. Arimidex in daily doses up to 10 mg has no effect on cortisol and aldosterone secretion, therefore, substitution of corticosteroids is not required when using the drug Arimidex.
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