Arimidex 1 mg kohlpharma Filmtabletten

Description

A highly selective non-steroidal aromatase inhibitor. Aromatase is an enzyme that converts androstenedione in peripheral tissues in postmenopausal women into estrone and further into estradiol. Reducing circulating estradiol levels has a therapeutic effect in breast cancer patients. In postmenopause the drug in a daily dose of 1 mg causes reduction of estradiol level by 80%.

Arimidex has no progestagenic, androgenic and estrogenic activity.

Arimidex in a daily dose of up to 10 mg has no effect on cortisol and aldosterone secretion (therefore, the drug does not require replacement administration of corticosteroids).

Contraindications

• Severe renal insufficiency (creatinine clearance less than 20 ml/min);
• moderate to severe hepatic insufficiency (safety and efficacy have not been established);
• concomitant therapy with tamoxifen;
• pediatric age (safety and efficacy have not been established)
• pregnancy;
• lactation (breastfeeding);
• hypersensitivity to anastrozole and other components of the drug.

The drug is not prescribed to women in premenopause.

Method of administration and dosage

Adults, including elderly patients, the drug is administered 1 mg orally 1 time/day, long-term. If signs of disease progression appear, the drug should be discontinued. As adjuvant therapy the recommended duration of treatment is 5 years.

Patients with mild and moderately expressed renal dysfunction do not require dose adjustment.

Patients with mild hepatic dysfunction do not require dose adjustment.

The tablet should be swallowed whole and drank with water. It is recommended to take the drug at the same time of the day.